Cu-SCys interactions are known to play a dominant role in determining the type 1 (T1) blue copper center with respect to both the electronic structure and electron transfer function. Despite this critical role must still be reviewed by mutagenesis studies without dramatic changes in the character of the T1 copper. We here report the conserved …
Monthly Archives: May 2020
Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay.
The prion protein (PrP) were involved in prion diseases such as Creutzfeldt-Jakob disease, in which the isoform mobile monomer his (PrP (C)) were recruited into the polymer self-propagating pathogenic misfolded proteins, and in Alzheimer’s disease, in where PrP (C) can act as a receptor to form synaptotoxic oligomeric amyloid-β (Aβ). There is considerable interest in …
Processes on the emergent landscapes of biochemical reaction networks and heterogeneous cell population dynamics: differentiation in living matters.
The idea of the pickup has been widely used in thinking about the nonlinear dynamics of organisms and biological phenomena as a system and as a process. The idea of a landscape with valleys and mountains encoding several attractors, however, has a rigorous foundation only for a closed, non-driven thermodynamics, chemical systems, such as proteins. …