Tag Archives: Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay.

The prion protein (PrP) were involved in prion diseases such as Creutzfeldt-Jakob disease, in which the isoform mobile monomer his (PrP (C)) were recruited into the polymer self-propagating pathogenic misfolded proteins, and in Alzheimer’s disease, in where PrP (C) can act as a receptor to form synaptotoxic oligomeric amyloid-β (Aβ). There is considerable interest in …

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